1. Can you please explain to me what changes take place in the body to cause a person to have…

1. Can you please explain to me what changes take place in the body to cause a person to have chronic fatigue syndrome (CFS). I am having difficulty understanding the pathology of this condition. 2. What is the best treatment for primary insomnia? Could benzodiazepines be used continuously? 3. Does tolerance develop to the hypnotic effect of trazodone and mianserin? Do these play a role in the treatment of primary insomnia?

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