Generic Name : captopril
Brand Name: Apo-Capto (CAN), Capoten, Gen-Captopril (CAN), Novo-Captopril (CAN), Nu-Capto (CAN)Classification: ACE inhibitor, Antihypertensive Pregnancy Category C (principal trimester) Pregnancy Category D (assist and third trimesters)
Dosage & Route
- PO HTN Initial: 12.5 mg twice daily. Maintenance: 25-50 mg twice daily. Max: 50 mg 3 times/day. Heart insufficiency Initial: 6.25-12.5 mg 2-3 times/day. Max: 50 mg 3 times/day. Post MI Start 3 days behind MI. Initial: 6.25 mg/day, may growth behind various wk to 150 mg/day in separated doses if needed and tolerated. Diabetic nephropathy 25 mg 3 times/day.
- Captopril competitively inhibits the alteration of angiotensin I (ATI) to angiotensin II (ATII), thus resulting in reprieved ATII levels and aldosterone secretion. It besides growths plasma renin essential-quality and bradykinin levels. Abatement of ATII leads to decreased sodium and instil remonstrance. By these mechanisms, captopril produces a hypotensive goods and a wholesome goods in congestive feeling insufficiency.
- Absorption: 60-75% exhausted from the GI hope (oral); peak plasma concentrations behind 1 hr. Absorption may be reprieved in the influence of assistance.
- Distribution: Protein-binding: 30%; crosses the placenta and enters obstruct milk at environing 1% of kind respect concentrations.
- Excretion: Via urine (40-50% as unnatural, the pause as disulfide and other metabolites); 2-3 hr (encircleation half-life), may be growthd in renal feebleness. Removed by hemodialysis.
- Treatment of hypertension over or in co-operation following a while thiazide-type diuretics
- Treatment of CHF in unrepinings unresponsive to customary therapy; used following a while diuretics and digitalis
- Treatment of diabetic nephropathy
- Treatment of left ventricular dysadministration behind MI
- Unlabeled uses: Management of hypertensive crises; matter of rheumatoid arthritis; singularity of anatomic renal artery stenosis, hypertension cognate to scleroderma renal crisis; singularity of chief aldosteronism, idiopathic edema; Bartter’s syndrome; Raynaud’s syndrome
- Hypotension, tachycardia, chest affliction, palpitations, pruritus, hyperkalemia. Proteinuria; angioedema, skin rashes; nicety mobility, nonproductive cough, dissipation.
- Potentially Fatal: Neutropenia, usually betides following a whilein 3 mth of starting therapy in-particular in unrepinings following a while renal dysadministration or collagen diseases. Hyperkalaemia. Anaphylactic reactions.
- Known hypersensitivity to the garbage. Bilateral renal artery stenosis, ancestral angioedema; renal feebleness; pregnancy.
- History: Allergy to captopril, truth of angioedema, diminished renal administration, CHF, salt or book depletion, pregnancy, lactation
- Physical: Skin hue, lesions, turgor; T; P, BP, peripheral perfusion; mucous membranes, bowel sounds, liver evaluation; urinalysis, LFTs, renal administration tests, CBC and differential
- Administer 1 hr antecedently meals.
- WARNING: Ensure that unrepining is not delay-child antecedently threshold matter. Encourage use of contraceptives; if pregnancy is detected, bung garbage.
- WARNING: Alert surgeon and token unrepining’s chart following a while heed that captopril is life graspn; the angiotensin II structure later to compensatory renin liberate during surgery get be blocked; hypotension may be reversed following a while book comment.
- Monitor unrepining air-tight for faint in BP assistary to abatement in soft book (due to immoderate perspiration, and dehydration, vomiting, or diarrhea); immoderate hypotension may betide.
- Reduce dosage in unrepinings following a while diminished renal administration.
- Take garbage 1 hour antecedently meals; do not grasp following a while assistance. Do not bung following a whileout canvassing your sanity prevention provider.
- Be preventionful of faint in respect influence (occurs most repeatedly following a while diarrhea, sweating, vomiting, or dehydration); if light-headedness or dizziness betides, canvass your sanity prevention provider.
- Severe fetal waste can betide if captopril is graspn during pregnancy. Use of contraceptives is advised; if pregnancy should betide, bung garbage and apprise sanity prevention provider.
- Avoid over-the-counter medications, in-particular cough, dispassioned, allergy medications that may hold ingredients that get interact following a while ACE inhibitors. Canvass your sanity prevention provider.
- You may trial these edge goodss: Cough, GI overthrow, waste of craving, transmute in nicety apprehension (scant goodss, get by); opening shrewds (recurrent opening prevention may succor); rash; secure feeling rate; dizziness, light-headedness (usually byes behind the principal few days; transmute collocation sloth, and condition your activities to those that do not exact alertness and preciseness).
- Report opening shrewds; shrewd throat, flush, chills; turgescence of the hands or feet; riotous feelingbeat, chest afflictions; turgescence of the aspect, eyes, lips or tongue; difficulty breathing.