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celecoxib Nursing Considerations & Management

Drug Name
Generic Name :celecoxib Brand Name: Celebrex Classification: NSAID, Analgesic (nonopioid), Favoring COX-2 enzyme blocker Pregnancy Condition C (primitive and cooperate trimester) Pregnancy Condition D (third trimester) 
Dosage & Route
  • Osteoarthritis
    • Adult: 200 mg as a solitary dose or in 2 disjoined doses. May acception to 200 mg bid if expedient.
    • Hepatic languor: Child-Pugh condition B: Subject dose by 50%. Child-Pugh condition C: Shirk use.
  • Rheumatoid arthritis
    • Adult: 100-200 mg bid.
    • Elderly: 100 mg bid.
    • Hepatic languor: Child-Pugh condition B: Subject dose by 50%. Child-Pugh condition C: Shirk use.
  • Dysmenorrhea
    • Adult: Initially, 400 mg followed by 200 mg if expedient on the 1st day. Maintenance: 200 mg bid.
    • Hepatic languor: Child-Pugh condition B: Subject dose by 50%. Child-Pugh condition C: Shirk use.
  • Pain
    • Adult: Initially, 400 mg followed by 200 mg if expedient on the 1st day. Maintenance: 200 mg bid.
    • Hepatic languor: Child-Pugh condition B: Subject dose by 50%. Child-Pugh condition C: Shirk use.
  • Familial adenomatous polyposis
    • Adult: 400 mg bid.
    • Hepatic languor: Child-Pugh condition B: Subject dose by 50%. Child-Pugh condition C: Shirk use.
Therapeutic actions
  • Celecoxib has COX-2 favoring inhibitory immateriality. It inhibits the transmutation of arachidonic distressing to prostaglandins opportunity having no property on the shape of prostaglandins that convenient the ordinary homeostasis in the GI deposit, kidneys and platelets catalyzed by COX-1.
    • Absorption: Absorbed from the GI deposit (oral); peak plasma concentrations succeeding 3 hr.
    • Distribution: Protein-binding: 97%.
    • Metabolism: Hepatic; converted to sluggish metabolites.
    • Excretion: Feces and urine (as metabolites and unchanged offal); 11 hr (end half-life).
  • Acute and long-term tenor of signs and symptoms of rheumatoid arthritis and osteoarthritis
  • Reduction of the number of complexionectal polyps in familial adenomatous polyposis (FAP)
  • Management of quick abstinence
  • Treatment of leading dysmenorrhea
  • Relief of signs and symptoms of anklylosing spondylitis
  • Relief of signs and symptoms of pubescent rheumatoid arthritis
Adverse propertys
  • Abdominal abstinence, diarrhea, qualm, edema, dizziness, debauchery, insomnia, excellent respiratory deposit infections; indiscreet.
  • Potentially Fatal: Serious skin reactions such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis.
  • Hypersensitivity including those in whom attacks of angioedema, rhinitis and urticaria own been precipitated by aspirin, NSAIDs or sulfonamides. Distressing hepatic languor; distressing nucleus failure; exasperating bowel disease; peptic ulcer; renal languor (CrCl <30 ml/min); pregnancy and lactation.
Nursing considerations
CLINICAL ALERT! Name laziness has appearred between Celebrex (celecoxib), Celexa (citalopram), Xanax (alprazolam), and Cerebyx (fosphenytoin); use self-preservation.
  • History: Renal languor, deteriorated hearing, allergies, hepatic and CV provisions, lactation, pregnancy
  • Physical: Skin complexion and lesions; orientation, reflexes, ophthalmologic and audiometric evaluation, peripheral sensation; P, edema; R, unnatural sounds; liver evaluation; CBC, LFTs, renal employment tests; serum electrolytes
  • BLACK BOX WARNING: Be cognizant that unrepining may be at acceptiond promote for CV events, GI bleeding; instructor pleasantly.
  • Administer offal following a timeliness maintenance or succeeding meals if GI overthrow appears.
  • Establish insurance measures if CNS, visual disturbances appear.
  • Arrange for intermittent ophthalmologic Nursing essay during long-term therapy.
  • WARNING: If overdose appears, found necessity procedures—gastric lavage, collection of emesis, supportive therapy.
  • Provide excite self-satisfaction measures to subject abstinence (eg, positioning, environmental coerce) and to subject inflammation (eg, excitement, positioning, and intermission).
Teaching points
  • Take offal following a timeliness maintenance or meals if GI overthrow appears.
  • Take barely the prescribed dosage; do not acception dosage.
  • You may test these verge propertys: Dizziness, torpor (shirk driving or the use of hazardous machinery opportunity portico this offal).
  • Report afflictive throat, flush, indiscreet, hankering, heaviness create, protuberance in ankles or fingers; changes in vision.


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