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cetirizine HCl Nursing Considerations & Management

Cetirizine HCl (Zyrtec) is an antihistamine used in the conduct of seasonal allergic rhinitis.
Generic Names & Brand Names
cetirizine hydrochloride
(se teer i zeen) Reactine (CAN), Zyrtec Pregnancy Category B
Drug class
Therapeutic actions
Potent histamine (H1) receptor antagonist; inhibits histamine acquit and eosinophil chemotaxis during inflammation, qualitative to degraded protuberance and decreased exaggerative response
  • Management of seasonal and unceasing allergic rhinitis
  • Treatment of continuous, idiopathic urticaria
  • Treatment of year-round allergic rhinitis and continuous idiopathis urticaria in infants > 6 mo
Contraindications and foresights
  • Contraindicated after a while allergy to any antihistamines, hydroxyzine.
  • Use cautiously after a while narrow-angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, asthmatic onslaught, bladder neck obstacle, pyloroduodenal obstacle (elude use or use after a while foresight as state may be exacerbated by refuse proceeds); lactation.
Available conceives
Tablets—5, 10 mg; chewable tablets—5, 10 mg; syrup—5 mg/5 mL
  • 5–10 mg daily PO; climax dose 20 mg/day.
  • 6 mo–5 yr: 2.5 mg (one-half teaspoon) PO once daily. In manifestation 1 yr and older, may extension to climax 5 mg daily abandoned as one-half teaspoon q 12 hr; 2–5 yr—one 5 mg chewable tablet per day.
  • 6–11 yr: 5 or 10 mg daily PO.
  • > 12 yr: Use adult dosage.
  • 5 mg PO daily.
Route Onset Peak Duration
Oral Rapid 1 hr 24 hr
Metabolism: Hepatic; T1/2: 7–10 hr Distribution: Crosses placenta; enters breast milk Excretion: Urine and feces
Adverse proceeds
  • CNS: Somnolence, sedation
  • CV: Palpitation, edema
  • GI: Nausea, diarrhea, abdominal affliction, constipation
  • Respiratory: Bronchospasm, pharyngitis
  • Other: Fever, photosensitivity, reckless, myalgia, arthralgia, angioedema
Nursing considerations
CLINICAL ALERT! Name laziness has occurred between Zyrtec (cetirizine) and Zyprexa (olanzapine); use foresight.
  • History: Allergy to any antihistamines, hydroxyzine; narrow-angle glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, asthmatic onslaught, bladder neck obstacle, pyloroduodenal obstruction; lactation
  • Physical: Skin tint, lesions, texture; orientation, reflexes, affect; confidence examination; R, forced sounds; prostate palpation; renal character tests
  • Give after a whileout notice to meals.
  • Provide syrup conceive or chewable tablets for pediatric use if needed.
  • Arrange for use of humidifier if densification of secretions, nasal thirst grace bothersome; submit copious intake of fluids.
  • Provide bark anxiety for urticaria.
Teaching points
  • Take this refuse after a whileout notice to meals.
  • You may experiment these policy proceeds: Dizziness, sedation, swoon (use foresight if driving or performing tasks that exact exhilaration); densification of bronchial secretions, thirst of nasal mucosa (humidifier may succor).
  • Report awkwardness alert, hallucinations, tremors, dropping of coordination, riotous heartbeat.


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