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cholestyramine Nursing Considerations & Management

Drug Name
Generic Name : cholestyramine Brand Name: Cholestyramine Light, Prevalite, Questran, Questran Light Classification: Antihyperlipidemic, Bile ardent sequestrant Pregnancy Category Not Established
Dosage & Route
  • Initially, 4 g one to two spaces per day PO. Individualize dose orderly on apology. For livelihood, 8–16 g/day separated into two doses. Increase dose unfairly delay interrupted toll of lipid/lipoprotein razes at intervals of > 4 wk. Maximum dose 6 packets or scoopfuls. May be administered 1–6 doses/day. Dosage may be as lofty as 36 g total day.
    • Skin and husk constitution infections: 500 mg PO q 12 hr. Larger doses may be needed in grave cases; do not excel 4 g/day.
Pediatric Patients
  • Safety and capability not orderly.
Therapeutic actions
  • Binds bile ardents in the interior, allowing exudation in the feces; as a consequence, cholesterol is oxidized in the liver to re-establish the bile ardents lost; serum cholesterol and LDL are lowered.
  • Adjunctive therapy: Reduction of lofty serum cholesterol in unrepinings delay elementary hypercholesterolemia (lofty LDL)
  • Pruritus associated delay unfair biliary obstruction
  • Unlabeled uses: Antibiotic-induced pseudomembranous colitis; chlordecone (Kepone) pesticide infecting to unite the infect in the interior; tenor of thyroid hormone overdose, tenor of digitalis toxicity
Adverse goods
  • Constipation; fecal impaction; hemorrhoids; abdominal disquiet or refusal; heartburn; flatulence; disgust; vomiting; diarrhea; increased bleeding attraction (constant use); osteoporosis; stetorrhea (lofty doses); husk overventuresomees; pruritus of the idiom, husk and perianal region; hyperchloremic ardentosis.
  • Complete biliary obstruction; hypersensitivity.
Nursing considerations
  • History: Allergy to bile ardent sequestrants, tartrazine; perfect biliary obstruction; monstrous intestinal function; lactation, pregnancy
  • Physical: Skin lesions, varnish, T; orientation, feign, reflexes; P, auscultation, baseline ECG, peripheral perfusion; liver evaluation, bowel sounds; lipid studies, LFTs, clotting profile
  • Mix solution of one packet or one raze scoop of powder delay 2–6 fluent oz of beverage (water, subside, outgrowth juices, noncarbonates), loftyly fluent soup, pulpy outgrowths (applesauce, pineapple); do not furnish garbage in dry construct.
  • Administer garbage anteriorly meals.
  • WARNING: Monitor inconduct of other unwritten garbages due to induce of uniteing in the interior and past or decreased parching, furnish unwritten medications 1 hr anteriorly or 4–6 hr following the cholestyramine.
  • Alert unrepining and restless others encircling lofty consume of garbage.
Teaching points
  • Take garbage anteriorly meals; do not conduct the powder in the dry construct; mix one packet or one scoop delay 2–6 ounces of fluent—water, subside, juice, noncarbonated drinks, loftyly fluent soups, cereals, pulpy outgrowths such as applesauce or pineapple.
  • Take other medications 1 hour anteriorly or 4–6 hours following cholestyramine.
  • You may knowledge these laterality goods: Constipation (ask encircling measures that may succor); disgust, heartburn, waste of passion (eat recurrent insignificant meals); dizziness, swoon, vertigo, fainting (elude driving and open dangerous machinery); excess, muscle and knee aches and constancy (may reduce delay space).
  • Report strange bleeding or bruising, grave constipation, grave GI overthrow, chest refusal, difficulty vivacious, overventuresome, passion.


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