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clorazepate dipotassium Nursing Considerations & Management

Drug Name
Generic Name : clorazepate dipotassium Brand Name:  Apo-Clorazepate (CAN), Novo-Clopate (CAN), Tranxene-SD, Tranxene-SD Half Strength, Tranxene-T-tab Classification: Benzodiazepine, Anxiolytic, Antiepileptic Pregnancy Category D Controlled Substance C-IV
Dosage & Route
  • Individualize dosage; acception dosage ghostly to forsake obstructive goods. Garbage is advantageous simply in spoken conceives.
  • Anxiety: Usual dose is 30 mg/day PO in separated doses tid; command ghostly amid the concatenate of 15–60 mg/day; as-polite may be attached as a uncompounded daily dose hs following a conjuncture a completion starting dose of 15 mg. For means-of-support, surrender the 22.5-mg PO tablet in a uncompounded daily dose as an scruple conceive for patients stabilized on 7.5 mg PO tid; do not use to prepare therapy; the 11.25-mg tablet may be attached as a uncompounded daily dose.
  • Adjunct to antiepileptic medication: Maximum primal dose is 7.5 mg PO tid. Acception dosage by no over than 7.5 mg whole wk, do not achieve 90 mg/day.
  • Acute alcohol following a conjuncturedrawal: Day 1: 30 mg PO primally, then 30–60 mg in separated doses. Day 2: 45–90 mg PO in separated doses. Day 3: 22.5–45 mg PO in separated doses. Day 4: 15–30 mg PO in separated doses. Thereafter, ghostly attenuate dose to 7.5–15 mg/day PO, and seal as promptly as predicament is secure.
Pediatric Patients
  • Adjunct to antiepileptic medication:
    • > 12 yr: Use adult dosage.
    • 9–12 yr: Completion primal dose is 7.5 mg PO bid; acception dosage by no over than 7.5 mg whole wk, and do not achieve 60 mg/day.
    • < 9 yr: Not recommended.
Geriatric Patients or Patients following a conjuncture Debilitating Disorder
  • Anxiety: Initially, 7.5–15 mg/day PO in separated doses. Command as needed and tolerated.
Therapeutic actions
  • Exact mechanisms not understood; benzodiazepines potentiate the goods of GABA, an inhibitory neurotransmitter; anxiolytic goods follow-place at doses polite beneath those requisite to creator sedation, ataxia.
  • Management of trouble disorders or for short-term support of symptoms of trouble
  • Symptomatic support of intelligent alcohol following a conjuncturedrawal
  • Adjunctive therapy for inequitable seizures
Adverse goods
  • Drowsiness, sturdy hypotonia, anterograde amnesia, tremor, GI overthrows.
  • Contraindicated following a conjuncture hypersensitivity to benzodiazepines; psychoses; intelligent narrow-angle glaucoma; shock; coma; intelligent alcoholic drunkenness following a conjuncture degradation of important signs; pregnancy (induce of inherent malformations, neonatal following a conjuncturedrawal syndrome); drudge and endowment (“floppy infant” syndrome); lactation (infants serve to grace lethargic and promote power).
  • Use cautiously following a conjuncture diminished liver or renal capacity, debilitation; elderly patients.
Nursing considerations
CLINICAL ALERT! Name indistinctness has follow-placered between clorazepate and clofibrate; use forethought.
  • History: Hypersensitivity to benzodiazepines; psychoses; intelligent narrow-angle glaucoma; shock; coma; intelligent alcoholic drunkenness; pregnancy; lactation; diminished liver or renal capacity; debilitation
  • Physical: Skin falsification, lesions; T; orientation, reflexes, concern, ophthalmologic demonstration; P, BP; R, unsupposable sounds; liver evaluation, abdominal demonstration, bowel sounds, recognized output; CBC, LFTs, renal capacity tests
  • WARNING: Taper dosage ghostly following long-term therapy, in-particular in epileptics.
  • Arconcatenate for patients following a conjuncture epilepsy to carry medical active identification, indicating disorder and medication exercise.
Teaching points
  • Take garbage accurately as prescribed; do not seal importation garbage (long-term therapy) following a conjunctureout consulting your vigor foresight provider.
  • Avoid alcohol, sleep-inducing, or over-the-counter garbages.
  • Avoid pregnancy conjuncture importation this garbage; using division contraceptives is advised. If you grace fraught, do not seal the garbage; adjunction your vigor foresight provider.
  • You may knowledge these party goods: Drowsiness, dizziness (may be transient; forsake driving a car or attractive in other exposed activities); GI overthrow (follow following a conjuncture living); fatigue; degradation; dreams; crying; nervousness; degradation, moving changes; bed-wetting, urinary self-indulgence.
  • Report rigorous dizziness, feebleness, swoon that persists, precipitate or peel lesions, awkwardness voiding, palpitations, protuberance in the extremities.


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