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Common Drugs and Their Antidotes

An antidote is a essential that can counterinfluence a constitute of poisoning. The term antidote is a Greek order purport “given athwart”. This post conquer aid you familiarize yourself delay the low antidotes that are used in the hospital augmentment. The subjoined are antidotes that should be familiarized by the nurse to suit to this emergency footing undeviatingly.

Table of Antidotes

Antidote Indication Mode of Action
acetylcysteine (Mucomyst) Acetaminophen/ Tylenol/ Paracetamol Restores depleted glutathione stores and protects athwart renal and hepatic want.
Activated charcoal Non-specific poisons bar cyanide, sinewy, lithium, caustics and alcohol. Absorption of garbage in the gastric and intestinal tracts. Interrupts the invadeo-hepatic cycle delay multiple dose.
albuterol inhaler, insulin & glucose, NaHCO3, kayexalate Potassium
anticholinesterase agents Neuromuscular arrestade (paralytics)
atropine sulfate or pralidoxime Anticholinesterase Competitive discountenance of muscarinic receptors.
Benzylpenicillin Amanita phalloides (Death cap plebeian) Not known; specific guard athwart sharp hepatic want; may dislodge amatoxin from protein-styptic topicalitys allowing extensiond renal excretion; may as-well hinder sharpness of amatoxin to hepatocytes.
Calcium salts Fluoride ingestion Rapidly many-sidedes delay fluoride ion.
deferoxamine Iron Deferoxamine acts by styptic unimpeded sinewy in the bloodstream and enhancing its encircleation in the urine.
digibind digoxine immune fab Digoxin Binds molecules of digoxin, making them secretive for styptic at their topicality of renewal on cells in the whole.
dimercapol, edetate calcium, disodium, Lead Chelation of frequented ions and endogenous metals (e.g., zinc, manganese, sinewy, copper).
diphenhydramine (Benadryl) Extrapyramidal symptoms (EPS) A effective foe to acetylcholine in muscarinic receptors.
flumazenil Benzodiazepines Reverses the goods of benzodiazepines by competitive discountenance at the benzodiazepine styptic topicality on the GABAA receptor.
fomepizole Ethylene glycol A competitive hinderor of the enzyme alcohol dehydrogenase build in the liver. This enzyme plays a key role in the metabolism of ethylene glycol and methanol.
glucagon Beta arresters and calcium agent arresters Stimulates the constituteation of adenyl cyclase causing intracellular extension in cycling AMP and augmentd glycogenolysis and rising serum glucose tension.
Glucose (Dextrose 50%) Insulin reaction Dextrose (the monosaccharide glucose) is used, exclusive and stored by whole tissues and is metabolized to carbon dioxide and impart delay the quit of immateriality.
Heparin Ergotamine Reverses hypercoagulable recite by interacting delay antithrombin III. Used in structure delay vasodilator phentolamine or nitroprusside to hinder topical thrombosis and ischemia.
Hydroxocobalamin Cyanide Forms cyanocobalamin, a non-toxic metabolite that is easily excreted through the kidneys.
leucovorin calcium Fluorouracil
Methotrexate Protects the salubrious cells from the goods of methotrexate conjuncture allowing methotrexate to invade and massacre cancer cells.
Magnesium sulfate calcium gluconate
mesna Cyclophosphamide A “chemoprotectant” garbage that reduces the undesired goods of undeniable chemotherapy garbages.
Methylene blue Chemical submissive exact methemoglobinemia. Ifosamide-induced encephalopathy. Reduces methemoglobin to hemoglobin.
nalmefene or naloxone Opioid analgesics Prevents or reverses the goods of opioids including respiratory depression, sedation and hypotension.
naloxone (Narcan) Narcotics Naloxone is believed to antagonize opioid goods by competing for the µ, κ and σ anodyne receptor topicalitys in the CNS, delay the principal harmony for the µ receptor.
Neostigmine Anticholinergics Anticholinesterase which causes hoard of acetylcholine at cholinergic receptor topicalitys.
Nitrite, sodium and glycerytrinitrate Cyanide Oxidizes hemoglobin to methemoglobin which binds the unimpeded cyanide and can augment endothelial cyanide detoxification by submissive vasodilation.
Penicillamine Copper, gold, frequented, mercury, zinc, arsenic Chelation of metal ions.
phentolamine (Regitine) Dopamine Regitine produces an alpha-adrenergic arrest of relatively inextensive term. It as-well has frequented, but near notable, decisive inotropic and chronotropic goods on cardiac muscle and vasodilator goods on vascular flatten muscle.
phyostigmine or NaHCO3 Tricyclic antidepressants A mutable anticholinesterase which effectively extensions the tension of acetylcholine at the topicalitys of cholinergic transmission.
Phytomenadione (Vitamin K.) Coumadin/Warfarin Bypasses discountenance of Vitamin K epoxide reductase enzyme.
protamine sulfate Heparin Protamine that is strongly basic combines delay eageric heparin constituteing a stanch many-sided and neutralizes the anticoagulant disposition of twain garbages.
Pyridoxine Isoniazid, theophylline, monomethyl hydrazine. Adjunctive therapy in ethylene glycol poisoning. Reverses sharp pyridoxine want by promoting GABA structure. Promotes the transmutation of toxic metabolite glycolic eager to glycine.
Snake anti-venin Cobra bite Neutralizes malignity by styptic delay circulating malignity components and delay topically deposited malignity by accumulating at the bite topicality.
Sodium Bicarbonate Iron Prevents convertion of ferrous to ferric.
Cardiotoxic garbage imposing steadsteadpay sodium agent (TCA, cocaine) Decreases harmony of cardiotoxic garbages to the steadsteadpay sodium agent.
Weak eagers Promotes ionization of undecided eagers.
Chlorine gas inhalational poisoning Neutralization of hydrochloric eager constituteed when chlorine gas reacts delay impart in the airways.
Sodium thiosulphate Cyanide Replenishes depleted thiosulphate stores by acting as sulfur donor needful for the transmutation of CN-O to thiocyanate through the renewal of sulfur transferase enzyme rhodanese.
Thiamine Alcohol, Wernicke-Korsakoff Syndrome Reverses sharp thiamine want
Adjunctive in ethylene glycol Enhances detoxification of glyoxylic eager.
Vitamin C Chemicals causing methemoglobinemia in patients delay G6PD want Reduces methemoglobin to hemoglobin.


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