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diphenhydramine hydrochloride Nursing Considerations & Management

Generic Name : diphenhydramine hydrochloride
Brand Name:
  • Oral: Allerdryl (CAN), AllerMax Caplets, Banophen, Banophen Allergy, Benadryl Allergy, Diphen AF, Diphenhist, Diphenhist Captabs, Genahist, Siladryl, Silphen Cough
  • Oral direction preparations: Benadryl, Tusstat
  • Parenteral preparations: Benadryl
Classification: Antihistamine, Anti-noise indisposition refuse, Sedative-hypnotic, Antiparkinsonian, Cough suppressant Pregnancy Category B
  • 25–50 mg q 4–8 hr PO.
  • Motion indisposition: Give liberal dose insuranceally 30 min precedently pitfall to noise, and reiterate precedently meals and at bedtime.
  • Nighttime slumber aid: 25–50 mg PO at bedtime.
  • Cough suppression: 25 mg q 4 hr PO, not to yield 150 mg in 24 hr.
  • 10–50 mg IV or occult IM or up to 100 mg if required. Maximum daily dose is 400 mg.
  • 12.5–25 mg tid–qid PO or 5 mg/kg/day PO or 150 mg/m2 per day PO. Maximum daily dose 300 mg.
  • Motion indisposition: Give liberal dose insuranceally 30 min precedently pitfall to noise and reiterate precedently meals and at bedtime.
  • Cough suppression:
    • 2–6 yr: 6.25 mg q 4 hr, not to yield 25 mg in 24 hr.
    • 6–12 yr: 12.5 mg q 4 hr PO, not to yield 75 mg in 24 hr.
  • 5 mg/kg/day or 150 mg/m2 per day IV or by occult IM injection. Maximum daily dose is 300 mg divided into four doses.
  • More likely to reason dizziness, sedation, syncope, toxic confusional states, and hypotension in antiquated endurings; use after a while self-preservation.
  • Diphenhydramine blocks histamine H1-receptors on effector cells of the GI charge, respect vessels and respiratory charge. It to-boot reasons sedation and has some anticholinergic exercise.
  • Relief of symptoms associated after a while incessant and seasonal allergic rhinitis; vasomotor rhinitis; allergic conjunctivitis; soft, uncomplicated urticaria and angioedema; organization of allergic reactions to respect or plasma; dermatographism; adjunctive therapy in anaphylactic reactions
  • Active and insurance tenor of noise indisposition
  • Nighttime slumber aid
  • Parkinsonism (including refuse-induced parkinsonism and extrapyramidal reactions), in the antiquated intolerant of over strong refuses, for softer contrives of the guess-work in other age groups, and in confederacy after a while centrally acting anticholinergic antiparkinsonian refuses
  • Syrup contriveulation: Suppression of cough due to colds or allergy
  • CNS valley, dizziness, muddiness, sedation; absurd stimulation in children; parching of bung, thickened respiratory secretion, blurring of trust, urinary retention; GI disturbances; respect dyscrasias.
  • Hypersensitivity ; neonates, lactation.
  • History: Allergy to any antihistamines, narrow-angle glaucoma, stenosing peptic abscess, symptomatic prostatic hypertrophy, asthmatic aggression, bladder neck obstacle, pyloroduodenal obstacle, third trimester of pregnancy, lactation
  • Physical: Skin falsification, lesions, texture; orientation, reflexes, affect; trust examination; P, BP; R, monstrous sounds; bowel sounds; prostate palpation; CBC after a while differential
  • Administer after a while living if GI capsize happens.
  • Administer syrup contrive if enduring is weak to choose tablets.
  • Monitor enduring defense, and adjust for structure of dosage to lowest feasible talented dose.
Teaching points
  • Take as prescribed; eschew superabundant dosage.
  • Take after a while living if GI capsize happens.
  • Avoid alcohol; solemn sedation could happen.
  • These verge effects may happen: Dizziness, sedation, trance (use self-preservation driving or performing tasks requiring sprightliness); epigastric pain, diarrhea or constipation (choose refuse after a while meals); dry bung (use general bung thrift, suck sugarless lozenges); thickening of bronchial secretions, parching of nasal mucosa (use a humidifier).
  • Report difficulty alert, hallucinations, tremors, mislaying of coordination, strange bleeding or bruising, visual disturbances, riotous heartbeat.


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