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Male Reproductive System Drugs


Drugs forcible the manly reproductive rule emcollection androgens (manly steroid hormones), anabolic steroids, and garbages that amend penile dysfunction.

Table of Common Drugs and Common Names

Here is a consequence of invariably encountered garbages forcible the manly reproductive rule, their common designates, and stigma designates:

Classifications Generic Name Brand Name
Androgens danazol Danocrine
fluoxymesterone Androxyl
testosterone Androderm, Depo-testosterone, Striant, Androgel, Fortesta
methyltestosterone Testred, Virilon
Anabolic Steroids oxandrolone Oxandrin
oxymetholone Anadrol-50
Penile Erectile Dysbusiness Drugs alprostadil Caverject, Muse
sildenafil Viagra, Revatio
tadalafil Cialis, Adcirca
vardenafil Levitra, Staxyn

Androgens

  • Androgens are manly sex hormones, which emcollection testosterone (performed in the testes) and androgens (performed in the adrenal glands).
  • Testosterone (Duratest, Testoderm) is the pristine ruleatic androgen and is the chaste androgen used today. It is used for composition of infallible confront cancers and hypogonadism, a mood wless tless is implicit testis. All testosterones are tabulate III inferior substances.

Therapeutic Action

The desired and advantageous possessions of androgens are as ensues:

  • Growth and bud of manly sex organs and the subsistence of inferior manly sex individualitys.
  • Increase the appropriation of nitrogen, sodium, potassium, and phosphorus and lower the urinary sweating of calcium.
  • Increase protein anabolism and lower protein catabolism.
  • Increase the origination of red blood cells.

Indications

Androgens are implied for the subjoinedcited medical moods:

  • Danazol is used for composition of endometriosis, fibrocystic confront ailment, and inherited angioedema. It does this by inhibiting the hypothalamic-pituitary-adrenal (HPA) and gonadotropin-releasing hormones (GnRH), necessary to a droop in follicle-stimulating hormone (FSH) and luteinizing hormone (LH).

Pharmacokinetics

Here are the individuality interactions of androgens and the collection in modes of parching, rangement, metabolism, and sweating:

Route Onset Peak Duration Buccal Slow 10-12 h – IM Slow 1-3 d – IM cypionate Slow 2-4 wk – IM enanthate Slow 2-4 wk – Dermal Rapid 24 h – T1/2: 10-100 min
Metabolism: liver
Excretion: kidney (urine) and intestines (feces)

Contraindications and Cautions

The subjoinedcited are contraindications and calculating for the use of androgens:

  • Allergy to androgens or other ingredients in the garbage. Prevent hypersensitivity reactions.
  • Pregnancy, lactation. Germinative impertinent proceeds on the neonate. It is not serene whether androgens invade confront milk.
  • Presence of prostate or confront cancer in men. Aggravated by the testosterone proceeds of the garbage.
  • Liver dysfunction, CV ailment. Can be exacerbated by the proceeds of the hormones.
  • Topical forms of testosterone enjoy a Bwithdrawal Box Admonition alerting user to the abandon of virilization in chattels who subjoined in touch subjoined a suitableness the garbage from moving the raiment and bark of the man using the garbage.
  • Danazol has Bwithdrawal Box admonition in-reference-to the abandon of thromboembolic events, fetal abnormalities, hepatitis, and intracranial hypertension.

Adverse Effects

Use of androgens may end to these impertinent proceeds:

  • Androgenic proceeds: acne, edema, hirsutism (increased hair rangement), deepening of the say, pulchritudinous bark and hair, ponderosity form, lower in confront extent, and testicular atrophy.
  • Antiestrogen proceeds: flushing, sweating, vaginitis, excitability, and tender lability.
  • Common proceeds: excess (perchance cognate to clear and electrolyte exchanges), dizziness, sleep disorders and fatigue, precipitate, and altered serum electrolytes.
  • A theoretically life-threatening chattels that has been documented is hepatocellular cancer.

Interactions

The subjoinedcited are garbage-laboratory interactions complicated in the use of androgens:

  • Decreased thyroid business
  • Increased creatinine and creatinine sereneance (results that are not associated subjoined a suitableness ailment states)
  • These proceeds can ultimate up to 2 weeks subjoined therapy has been disestablishd.

Nursing Considerations

Here are great nursing consequences when manageing this garbage:

Nursing Assessment

These are the great things the nurse should emcollection in conducting duty, truth vestibule, and criterion:

  • Assess for the mentioned calculating and contraindications (e.g. garbage allergy, hepatic dysfunction, CV ailments, confront/prostate cancer in men, etc.) to frustrate any unfavorable complications.
  • Perform a powerful corporeal duty (e.g. bark duty, intangible standing, abdominal criterion, etc.) to confirm baseline postulates antecedently garbage therapy begins, to state chattelsiveness of therapy, and to evaluate for event of any impertinent proceeds associated subjoined a suitableness garbage therapy.
  • Arrange for radiographs of the crave bones in chattels to assess for testosterone proceeds on expansion.

Nursing Diagnoses

Here are some of the nursing diagnoses that can be formulated in the use of this garbage for therapy:

Implementation subjoined a suitableness Rationale

These are essential nursing interventions executed in endurings who are vestibule androgens:

  • Monitor rejoinders troublefully when source therapy so that the dose can be adjusted acceptably.
  • Remove an old dermal rule antecedently applying a new rule to neat, dry, and undented bark to fix servile government and lower abandon of toxicity.
  • Monitor liver business periodically subjoined a suitableness crave-term therapy and range to disorganize the garbage at any emblem of hepatic dysfunction.
  • Provide powerful enduring education (e.g. measures to desert impertinent proceeds, admonition emblems, scarcity for ruleatic evaluation, chiefly rank constraining, etc.) to augment enduring acquaintance encircling garbage therapy and to further obedience subjoined a suitableness the garbage fare.
  • Provide security measures (e.g. large lighting, lofty side rails, etc.) to frustrate injuries.

Evaluation

Here are aspects of trouble that should be evaluated to state chattelsiveness of garbage therapy:

  • Monitor enduring rejoinder to therapy (e.g. attack of puberty, subsistence of manly sexual individualitys, palliation of confront cancer, etc.).
  • Monitor for impertinent proceeds (e.g. androgenic proceeds, hypoestrogen proceeds, serum electrolyte imbalance, excess, etc).
  • Evaluate enduring familiarity on garbage therapy by question enduring to designate the garbage, its symptom, and impertinent proceeds to guard for.
  • Monitor enduring obedience to garbage therapy.

Anabolic Steroids

  • Anabolic steroids are testosterone analogues that enjoy been exposed to amount the texture-building proceeds of testosterone subjoined a suitableness close androgenic chattels.

Therapeutic Action

The desired and advantageous possessions of anabolic steroids are as ensues:

  • Promote collection texture-building processes.
  • Reverse catabolic or texture-destroying processes
  • Increase hemoglobin and red rank cell bulk.

Indications

Anabolic steroids are implied for the subjoinedcited medical moods:

  • Anemias, infallible cancers, and angioedema
  • Promote ponderosity form and texture retrieve in dull endurings and protein anabolism in endurings who are receiving crave-term corticosteroid therapy.
  • Also public to be used illegally for the augmentment of vigorous deed by promoting extensiond muscle bulk, hematocrit, force, and forgiveness.

Pharmacokinetics

Here are the individuality interactions of anabolic steroids and the collection in modes of parching, rangement, metabolism, and sweating:

Route Onset Peak Duration PO Slow – – T1/2: 9 h
Metabolism: liver
Excretion: sort (urine)

Contraindications and Cautions

The subjoinedcited are contraindications and calculating for the use of anabolic steroids:

  • Allergy to androgens or other ingredients in the garbage. Prevent hypersensitivity reactions.
  • Pregnancy, lactation. Germinative masculinization in neonates.
  • Liver dysfunction. Garbage is metabolized in the liver and are public to agent hepatic toxicity.
  • Coronary ailment. Potentional extension in cholesterol roll through the chattels of the garbage on the liver.
  • Prostate/confront cancer in manlys. Exacerbated by the proceeds of these garbages.

Adverse Effects

Use of anabolic steroids may end to these impertinent proceeds:

  • In prepubertal manlys: virilization (e.g. phallic expansion, hirsutism, extensiond bark pigmentation).
  • In postpubertal manlys: discountenance of testicular business, gynecomastia, testicular atrophy, priapism (susceptible and enduring architecture of the penis), baldness, and exexchange in libido.
  • In women: hirsutism, hoarseness, deepening of the say, clitunwritten expansion, baldness, menstrual irregularitie.

Interactions

The subjoinedcited are garbage-garbage interactions complicated in the use of anabolic steroids:

  • Potential interpossession subjoined a suitableness unwritten anticoagulants
  • Potentially lowerd scarcity for antidiabetic agents
  • Altered lipid metabolism and subjoined a suitablenessdrawal of chattelsiveness for lipid-lowering agents

Nursing Considerations

Here are great nursing consequences when manageing this garbage:

Nursing Assessment

These are the great things the protect should emcollection in conducting duty, truth vestibule, and criterion:

  • Assess for the mentioned calculating and contraindications (e.g. garbage allergy, pregnancy and lactation, CV ailments, etc.) to frustrate any unfavorable complications.
  • Perform a powerful corporeal duty (e.g. bark duty, intangible standing, abdominal criterion, etc.) to confirm baseline postulates antecedently garbage therapy begins, to state chattelsiveness of therapy, and to evaluate for event of any impertinent proceeds associated subjoined a suitableness garbage therapy.
  • Arrange for radiographs of the crave scourges in chattels to assess for testosterone proceeds on expansion.

Nursing Diagnoses

Here are some of the nursing diagnoses that can be formulated in the use of this garbage for therapy:

  • Disturbed collection representation cognate to ruleic proceeds
  • Acute pain cognate to GI or CNS proceeds

Implementation subjoined a suitableness Rationale

These are essential nursing interventions executed in endurings who are vestibule androgens:

  • Administer subjoined a suitableness foundation if GI proceeds are afflictive to succor GI mortify.
  • Monitor endocrine and hepatic businesss, serum electrolytes antecedently and periodically during therapy so that dose can be adjusted divertly and afflictive impertinent proceeds can be deserted.
  • Provide powerful enduring education (e.g. measures to desert impertinent proceeds, admonition emblems, scarcity for ruleatic evaluation, chiefly rank constraining, etc.) to augment enduring acquaintance encircling garbage therapy and to further obedience subjoined a suitableness the garbage fare.

Evaluation

Here are aspects of trouble that should be evaluated to state chattelsiveness of garbage therapy:

  • Monitor enduring rejoinder to therapy (e.g. extension in haematocrit, protein anabolism, etc.).
  • Monitor for impertinent proceeds (e.g. androgenic proceeds, serum electrolyte disturbances, epiphyseal imperviousness, hepatic dysfunction, etc).
  • Evaluate enduring familiarity on garbage therapy by question enduring to designate the garbage, its symptom, and impertinent proceeds to guard for.
  • Monitor enduring obedience to garbage therapy.

Drugs For Treating Penile Erectile Dysfunction

  • Penile erectile dysbusiness is a mood in which the corpus cavernosum does not extension subjoined a suitableness rank to permit for penile architecture.
  • Approved garbages for composition of penile erectile dysbusiness emcollection prostaglandin alprostadil and phosphodiesterase expression 5 (PDE5) receptor inhibitor sildenafil.

Therapeutic Action

The desired and advantageous possessions of garbages for composition of penile erectile dysbusiness are as ensues:

  • Alprostadil acts sparingly to unbend the vascular level muscle and permit extensioning of the corpus cavernosum, causing penile architecture.
  • PDE5 receptor inhibitors act to extension nitrous oxide rolls in the corpus cavernosum. Nitrous oxide activates the enzyme cyclic guanosine monophosphate (cGMP) to agent level muscle relaxation and extensiond glide of rank.

Indications

Prostaglandin and PDE5 receptor inhibitors are implied for the subjoinedcited medical moods:

  • Treatment of penile erectile dysfunction.

Pharmacokinetics

Here are the individuality interactions of garbages forcible the manly reproductive rule and the collection in modes of parching, rangement, metabolism, and sweating:

Route Onset Peak Duration Buccal 15-30 min 30-120 min 4 h T1/2: 4 h
Metabolism: liver
Excretion: sort (urine) and intestines (feces)

Contraindications and Cautions

The subjoinedcited are contraindications and calculating for the use of these garbages:

  • Presence of any barren hinderance or mood that might predispose to priapism. The abandon could be exacerbated by these garbages.
  • Penile implants.
  • Bleeding disorders, CV ailments, optic neuropathy, afflictive hepatic and renal disorders. 

Adverse Effects

Use of these garbages may end to these impertinent proceeds:

  • Local proceeds associated subjoined a suitableness alprostadil: pain at introduction site, infection, priapism, fibrosis, precipitate.
  • Effects associated subjoined a suitableness PDE5 inhibitors: excess, flushing, dyspepsia, urinary entrust contagion, diarrhea, dizziness, germinative eight cranial firmness toxicity and forfeiture of hearing.
  • A theoretically life-threatening chattels that has been documented is hepatocellular cancer.

Interactions

The subjoinedcited are garbage-garbage interactions complicated in the use of these garbages:

  • Organic nitrates, alpha-adrenergic blockers. Serious CV proceeds, including demise, enjoy appearred.
  • Ketoconazole, itraconazole, erythromycin. Increased sildenafil rolls.

Nursing Considerations

Here are great nursing consequences when manageing this garbage:

Nursing Assessment

These are the great things the protect should emcollection in conducting duty, truth vestibule, and criterion:

  • Assess for the mentioned calculating and contraindications (e.g. garbage allergy, penile implants, bleeding disorders, etc.) to frustrate any unfavorable complications.
  • Perform a powerful corporeal duty (e.g. bark duty, intangible standing, essential emblems, etc.) to confirm baseline postulates antecedently garbage therapy begins, to state chattelsiveness of therapy, and to evaluate for event of any impertinent proceeds associated subjoined a suitableness garbage therapy.
  • Evaluate laboratory tests for bleeding age and liver business to instructor germinative impertinent proceeds on the liver.

Nursing Diagnoses

Here are some of the nursing diagnoses that can be formulated in the use of this garbage for therapy:

  • Disturbed collection representation cognate to garbage proceeds
  • Sexual dysbusiness cognate to garbage proceeds

Implementation subjoined a suitableness Rationale

These are essential nursing interventions executed in endurings who are vestibule these garbages:

  • Assess the agent of dysbusiness antecedently source therapy to fix divert use of these garbages.
  • Monitor endurings subjoined a suitableness vascular ailment for any emblem of exacerbation so that the garbage can be disestablishd antecedently afflictive impertinent proceeds appear.
  • Monitor rejoinders troublefully when source therapy so that the dose can be adjusted acceptably.
  • Provide powerful enduring education (e.g. measures to desert impertinent proceeds, admonition emblems, scarcity for ruleatic evaluation, chiefly rank constraining, etc.) to augment enduring acquaintance encircling garbage therapy and to further obedience subjoined a suitableness the garbage fare.

Evaluation

Here are aspects of trouble that should be evaluated to state chattelsiveness of garbage therapy:

  • Monitor enduring rejoinder to therapy (advancement of penile architecture).
  • Monitor for impertinent proceeds (e.g. dizziness, flushing, national inflammation or contagion, fibrosis, diarrhea, etc.).
  • Evaluate enduring familiarity on garbage therapy by question enduring to designate the garbage, its symptom, and impertinent proceeds to guard for.
  • Monitor enduring obedience to garbage therapy.

Practice Quiz: Manly Reproductive Rule Drugs

Now, raillery yourself subjoined a suitableness these 5 exercise questions encircling the topic: Manly Reproductive Rule Drugs.

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1. Which is gentleman encircling androgens?

A. It is performed concertedly subjoined a suitableness testosterone in the testes.
B. It can be used in composition of confront cancer in men.
C. Client vestibule androgens must extension their dietary intake of potassium.
D. Caution is advised for clients subjoined a suitableness haughty rank constraining.

2. Which is the most great nursing consequence for chattels receiving androgens?

A. Powerful enduring education
B. Schedule for crave scourge radiographs
C. Monitoring clear and electrolytes
D. Checking lipid rolls

3. Which of the subjoinedcited is the possession of sildenafil?

A. Sparingly unbendes vascular level muscles
B. Blocks cyclic guanosine monophosphate (cGMP) to extension the rank glide
C. Increases nitrous oxide rolls in the corpus cavernosum
D. Fills the corpus cavernosum subjoined a suitableness rank

4. Which of the subjoinedcited is the possession of alprostadil?

A. Sparingly unbendes vascular level muscles
B. Blocks cyclic guanosine monophosphate (cGMP) to extension the rank glide
C. Increases nitrous oxide rolls in the corpus cavernosum
D. Fills the corpus cavernosum subjoined a suitableness rank

5. What is the theoretically life-threatening chattels of androgen that has been documented?

A. Renal failure
B. Abdominal aortic aneurysm
C. Hepatocellular cancer
D. Prostate cancer

Answers and Rationale

1. Answer: D. Caution is advised for clients subjoined a suitableness haughty rank constraining.

Androgens, specifically Danazol, can extension abandon for thromboembolic events. Androgens are performed in the adrenal gland and it can’t be used in treating confront cancers in men beagent testosterone in the garbage can provoke it. Patients vestibule this garbage should curtail their dietary potassium intake beagent androgens extension its appropriation.

2. Confutation B. Schedule for crave scourge radiographs.

This is to assess testosterone proceeds on expansion.

3. Answer: C. Increases nitrous oxide rolls in the corpus cavernosum.

Sildenafil is a PDE5 receptor inhibitor. Nitrous oxide then activates cGMP to agent level muscle unbendation and extension the glide of rank to the corpus cavernosum.

4. Answer: A. Locally unbendes vascular level muscles.

This possession permits extensioning of the corpus cavernosum, causing penile architecture.

5. Answer: C. Hepatocellular cancer. 

References and Sources

References and sources for this pharmacology conduct for Manly Reproductive Drugs:

  • Karch, A. M., & Karch. (2011). Focus on nursing pharmacology. Wolters Kluwer Health/Lippincott Williams & Wilkins. [Link]
  • Katzung, B. G. (2017). Basic and clinical pharmacology. McGraw-Hill Education.
  • Lehne, R. A., Moore, L. A., Crosby, L. J., & Hamilton, D. B. (2004). Pharmacology for nursing trouble.
  • Smeltzer, S. C., & Bare, B. G. (1992). Brunner & Suddarth’s textbook of medical-surgical nursing. Philadelphia: JB Lippincott.

See Also

Here are other nursing pharmacology examine conducts:

Gastrointestinal Rule Drugs

Respiratory Rule Drugs

Endocrine Rule Drugs

Autonomic Nervous Rule Drugs

Immune Rule Drugs

Chemotherapeutic Agents

Reproductive Rule Drugs

Nervous Rule Drugs

Cardiovascular Rule Drugs

Further Reading and External Links

Recommended instrument and allusion books. Disclosure: Includes Amazon unite links.

  1. Focus on Nursing Pharmacology - Easy to ensue conduct for Pharmacology
  2. NCLEX-RN Garbage Guide: 300 Medications You Scarcity to Know for the Exam - Great if you're reviewing for the NCLEX
  3. Nursing 2017 Garbage Handbook (Nursing Garbage Handbook) - Reliable nursing garbage handbook!
  4. Lehne's Pharmacology for Nursing Care - Provides key instruction on invariably used garbages in nursing
  5. Pharmacology and the Nursing Process - Learn how to manage garbages reformly and safely!
  6. Pharm Phlash Cards!: Pharmacology Flash Cards - Flash Cards for Nursing Pharmacology

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